Thousands of systematic reviews are now published in the Cochrane Database of Systematic Reviews, presenting critical summaries of the evidence. #Operations research an introduction chapter 22 trial#Iain Chalmers’ vision of “a library of trial overviews which will be updated when new data become available” (Chalmers 1986), became the mission and founding purpose of Cochrane. Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Chapter 22: Prospective approaches to accumulating evidence. This chapter should be cited as: Thomas J, Askie LM, Berlin JA, Elliott JH, Ghersi D, Simmonds M, Takwoingi Y, Tierney JF, Higgins HPT. Sequential methods may, however, be used in the context of a prospectively planned series of randomized trials. They should not be used for the main analyses, or to draw main conclusions. They are usually undertaken by a collaborative group including authors of the studies to be included, and they usually collect and analyse individual participant data.įormal sequential statistical methods are discouraged for standard updated meta-analyses in most circumstances for Cochrane Reviews. New technologies and better processes for data storage and reuse are being developed to facilitate the rapid identification and synthesis of new evidence.Ī prospective meta-analysis is a meta-analysis of studies (usually randomized trials) that were identified or even collectively planned to be eligible for the meta-analysis before the results of the studies became known. They are useful in rapidly evolving fields where research is published frequently. Living systematic reviews are systematic reviews that are continually updated, with new evidence being incorporated as soon as it becomes available. It is difficult to know when a given review might become out of date, but tools are available to assist in identifying when a review might need updating. Cochrane Reviews should reflect the state of current knowledge, but maintaining their currency is a challenge due to resource limitations.
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